UNRAVELING A THREE-STEP SPATIOTEMPORAL MECHANISM OF TRIGGERING OF RECEPTOR-INDUCED NIPAH VIRUS FUSION AND CELL ENTRY.

Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry.

Membrane fusion is essential for entry of the biomedically-important paramyxoviruses into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by paramyxoviral infections [e.g.those of the deadly Nipah virus (NiV)].For most paramyxoviruses, membrane fusion requires two viral glycoproteins.Upon receptor

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Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts

Abstract Background Systematic screening of all colorectal tumors for Lynch Syndrome (LS) has been recommended since 2009.Currently, implementation of LS screening in healthcare systems remains variable, likely because LS screening involves the complex coordination of multiple departments and individuals across the healthcare system.Our specific ai

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