Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry.
Membrane fusion is essential for entry of the biomedically-important paramyxoviruses into their host cells (viral-cell fusion), and for syncytia formation (cell-cell fusion), often induced by paramyxoviral infections [e.g.those of the deadly Nipah virus (NiV)].For most paramyxoviruses, membrane fusion requires two viral glycoproteins.Upon receptor